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Some clinical effects of midazolam premedication in propofol-induced and isoflurane-maintained anaesthesia in dogs during ovariohysterectomy

G.F. Stegmann, L. Bester

Journal of the South African Veterinary Association; Vol 72, No 4 (2001), 214-216. doi: 10.4102/jsava.v72i4.655

Submitted: 09 July 2001
Published:  09 July 2001


In a randomised, placebo-controlled clinical trial, anaesthesia was induced with propofol (4 mg/kg) after intravenous premedication with or without midazolam (0.1 mg/kg), in a group of 8 dogs scheduled for ovariohysterectomy. Midazolam administration induced acute behavioural changes, and increased reflex suppression after propofol induction. Compared to the control group, the dose required to obtain loss of the pedal reflex was significantly reduced by 37%, and the end-tidal isoflurane concentration during mainte-nance, reduced by 23 %.

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Author affiliations

G.F. Stegmann,
L. Bester,


Anaesthesia; Dogs; Isoflurane; Midazolam; Premedication; Propofol


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ISSN: 1019-9128 (print) | ISSN: 2224-9435 (online)

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