The effects of prolonged oral administration of the disinfectant calcium hypochlorite in Nigerian commercial cockerels

Authors

  • Temitayo O Iji Federal College of Animal Health and Production Technology
  • Ademola A Oyagbemi University of Ibadan
  • Odunayo I Azeez University of Ibadan

Abstract

This study was designed to investigate the effects of prolonged oral administration of calcium hypochlorite in the drinking water of commercial cockerels. It was carried out in order to ascertain probable toxicity associated with prolonged exposure to calcium hypochlorite. Thirty-two healthy birds were used; they were grouped into four groups of eight. Group 1, which served as the control, received 10 mL/kg body weight of physiological saline. Groups 2, 3 and 4 received 0.0375 g, 0.375 g and 0.75 g of calcium hypochlorite per 10 litres of drinking water for six weeks respectively. Six weeks after the administration of calcium hypochlorite,
blood was collected from the jugular vein to assess liver function, lipid profiles and for markers of oxidative stress. The results revealed a significant (p < 0.05) increase in alanine aminotransferase activity in a dose-dependent manner when compared with the control. Also, there was a significant (p < 0.05) increase in aspartate aminotransferase and alkaline phosphatase activity. Similarly, there was a significant (p < 0.05) increase in total cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein levels compared with the control. There was a significant increase in malondialdehyde and hydrogen peroxide
generation with a concomitant significant (p < 0.05) decrease in serum glutathione level in a dose-dependent manner when compared with the control. In this study, calcium hypochloriteinduced hepatic damage via oxidative stress and decrease in antioxidant defense system was found. Therefore, prolonged exposure of chickens to calcium hypochlorite is potentially
harmful.

Author Biographies

  • Temitayo O Iji, Federal College of Animal Health and Production Technology

    Federal College of Animal Health and Production Technology, Moor Plantation, Nigeria

  • Ademola A Oyagbemi, University of Ibadan

    Departments of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Nigeria

  • Odunayo I Azeez, University of Ibadan

    Departments of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Nigeria

Downloads

Published

2021-12-06

Issue

Section

Original Research