Immunohistochemical study of a canine neurofibroma

Authors

  • Hamidreza Fattahian Islamic Azad University
  • Pejman Mortazavi Islamic Azad University
  • Hamidreza Moosavian University of Tehran
  • Roozbeh Moridpour Islamic Azad University
  • Hamid Mohyeddin Islamic Azad University

Abstract

Accurate diagnostic approaches to differentiate peripheral nerve sheet tumours from others have not been firmly established. The aim of this case report was to diagnose neurofibroma using a combination of diagnostic imaging, histopathology and immunohistochemistry, which were applied to a canine neurofibroma arising in the left mandible. The tumour was surgically excised and examined histologically. Round or spindle cells, with elongated, dense and homogenous chromatin and pale cytoplasm typical of Schwann cells in an abundant fibromyxomatous stroma, with ruby collagen fibres were seen. Immunohistochemistry demonstrated that S-100 and vimentin were more than 70% positive. Neurofibroma may therefore be recognisable using markers such as S-100 and vimentin. 

Author Biographies

  • Hamidreza Fattahian, Islamic Azad University

    Department of Surgery, Science and Research Branch, Islamic Azad University, Iran

  • Pejman Mortazavi, Islamic Azad University

    Department of Pathology, Science and Research Branch, Islamic Azad University, Iran

  • Hamidreza Moosavian, University of Tehran

    Department of Clinical Sciences, University of Tehran, Iran

  • Roozbeh Moridpour, Islamic Azad University

    Department of Surgery, Science and Research Branch, Islamic Azad University, Iran

  • Hamid Mohyeddin, Islamic Azad University

    Department of Clinical Sciences, Garmsar Branch, Islamic Azad University, Iran

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Published

2021-12-03

Issue

Section

Case Report