Effect of percutaneous transthoracic lung biopsy on oxidative metabolism in sheep

Authors

  • Andreza A Silva São Paulo State University
  • Danilo O.L. Ferreira São Paulo State University
  • Bianca P Santarosa São Paulo State University
  • Adriano Dias São Paulo State University
  • Débora C Damasceno São Paulo State University
  • Roberto C Gonçalves São Paulo State University

Abstract

This study aimed to assess the effect of percutaneous transthoracic lung biopsy on the oxidative metabolism of sheep by measuring the oxidative stress markers of superoxide dismutase (SOD), total glutathione (GSH-t), peroxidase (GSH-Px) and thiobarbituric acid reactive substances (TBARS) in the red cells of these animals. Blood samples were collected from 20 clinically healthy sheep prior to, and 30 min after, percutaneous transthoracic lung biopsy. After biopsy, there was a significant decrease (p < 0.05) in SOD and GSH-Px activity, with no significant change (p ≥ 0.05) in GSH-t and TBARS concentrations. These results showed that percutaneous transthoracic lung biopsy did not significantly affect the oxidative metabolism of sheep 30 min after the procedure, which may be used widely in this species without causing serious tissue damage.

Author Biographies

  • Andreza A Silva, São Paulo State University

    Department of Veterinary Clinics, São Paulo State University, Brazil

  • Danilo O.L. Ferreira, São Paulo State University

    Department of Veterinary Clinics, São Paulo State University, Brazil

  • Bianca P Santarosa, São Paulo State University

    Department of Veterinary Clinics, São Paulo State University, Brazil

  • Adriano Dias, São Paulo State University

    Research Support Center, São Paulo State University, Brazil

  • Débora C Damasceno, São Paulo State University

    Department of Gynaecology and Obstetrics, São Paulo State University, Brazi

  • Roberto C Gonçalves, São Paulo State University

    Department of Veterinary Clinics, São Paulo State University, Brazil

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Published

2021-12-03

Issue

Section

Original Research